Interests: Physical Chemistry
Ph. D. Chemical Engineering, University of Minnesota, June 1986.
Advisors: H. Ted Davis and L. E. Scriven; Enhanced Petroleum Recovery/Surfactant Microstructures Group.
Thesis: "Studies in the Microstructure of Microemulsions".
M. S. Mathematics, University of Minnesota, May 1982.
1999 – 2011: V.P. Scientific Affairs at Lyotropic Therapeutics, Inc. Principal scientist, inventor of LyoCell® and Hydrogard™technologies, and leader of research effort focusing on novel injectable and ophthalmic drug-delivery systems, interactions between lipid systems/microparticles and biological systems, drug stabilization, and product development. In charge of design, production, and scale-up of LyoCell® microparticle formulations, and human/animal testing in collaboration with CRO's, contract manufacturers, and industrial partners. Also developed solution formulations incorporating novel Hydrogard™technology for stabilizing hydrolytically-unstable drug molecules, and liquid crystal-based platforms for the diagnostics arena. Instrumental in raising of over $13MM funding from private and industrial sources. Portfolio includes one lead product successfully tested in Phase I clinical trial, a second product subject to the Animal Rule successfully tested in the pivotal animal model, and 3 other animal-tested injectable products; one product is ~12 months from FDA approval.
1995 - 1999: Principal Scientist at SelectRelease, L.C. Developed oral controlled-release formulations based on synergistic combinations of lipids/surfactants and novel crystalline and polymeric coating materials. Particular focus on formulations for intestinal release. Pharmaceutical formulation work with photodynamic therapy agents led to successful animal tests demonstrating sustained release leading to tumor necrosis. Experimental work and oversight of research and development activities, analysis and report/proposal writing, with input into strategic planning, intellectual property and contracting, and technology acquisition. The pharmaceutical rights to the technology were sold to Lyotropic Therapeutics in 1999.
1991 - 1995: Assistant Professor, Biomaterials Dept. and Department of Oral Surgery, SUNY Buffalo; also adjunct faculty member in Biophysics and Chemistry Depts. Research in nanoporous polymers for bioseparations (filtration, chromatography, bioassays), and superporous/superabsorbent hydrogels incorporating a wide range of polymers, prepolymers and monomers including novel polymerizable lipids and surfactants. Polymerization methods included radical, ring-opening metathesis, and autoxidative-based. Taught biophysics, biomaterials, and a post-graduate polymers course of my own design and implementation. On the faculty of the NSFCenterfor Biosurfaces researching biocompatibility, bioadhesion, tissue compliance, and biofilm characterization. Contract research for Edgewood's Army research facility working on detection of viral warfare threats.
1987 ‑ 1991: Guest Researcher, Univ. of Lund, Sweden, with Hakan Wennerström and Björn Lindman in Physical Chemistry 1 Dept., a world-renowned department in colloid and interface science. Research focused on lyotropic liquid crystals, and the polymerization thereof. Funded by NFR (Swedish NSF) and by STU (Swedish Board of Technical Development) for first 2 years; after that I independently funded by arrangements with various industries including Costar, Corp., Union Carbide, and Pharmacia LKB. Supervised one graduate student (Ph.D. Thesis 3/1992).
1986 ‑ 1987: Post-doctoral fellow with the Polymer Science and Engineering and the Mathematics Departments of the Univ. of Massachusetts at Amherst, with E. L. Thomas and David Hoffman. Research focused on block copolymers, primarily the modeling of thermodynamics and morphology in complex 3-dimensional microstructures.
1982 ‑ 1986: Director of X‑ray Scattering Facility at the Univ. of Minnesota. While a graduate student, responsible for all matters concerning the operation of the lab, which housed a Siemens D‑500 Diffractometer with computer interfacing, and a modified Kratky small‑angle camera with a position‑sensitive detector. Instrument maintenance, training of users, billing and records, data analysis.
OTHER SKILLS, AFFILIATIONS AND AWARDS.
Awards and societies: Graduation with high distinction; Tau Beta Pi, Phi Kappa Phi; Runner-up in 1993 Niagara Frontier Inventor of the Year Award; Finalist in 1997 Richmond's New Technology of the Year; Runner-up in 1988 "Innovation Cup" invention contest sponsored by a Swedish technical newspaper (Dagens Industri); member American Association of Pharmaceutical Scientists (AAPS), and American Chemical Society (ACS); Strathmore's Who's Who; Virginia Science Resource Network, Virginia Academy of Science, National Directory of Scientific Experts.
Instrumentation skills. TEM/SEM, ultrafiltration (including hardware/system design), small- and wide-angle X-ray diffraction, pulsed-gradient NMR, aerosol monitoring, particle characterization with light scattering as well as aerosol techniques, polarizing, fluorescence and DIC optical microscopy, Raman spectroscopic confocal microscopy, IR, NMR (chemical shifts), UV-Vis, ellipsometry, electrophoresis and liquid chromatography. Aerosol generation and characterization expertise includes condensation particle counters, differential mobility analyzers, electrospray nebulizers, together with a strong background in the characterization of submicron/nanoscale particle characterization via a range of techniques. Short course certifications in rheology, DSC, XRD, and laser particle sizers. Excellent skills in optical instrumentation such as microscopes, elliposometers and telescopes including design of new optical measurement techniques.
Mathematics/modeling/computer skills. Strong computing skills ranging from PC's to mainframe supercomputing, including innovative state-of-art graphics dating back to the earliest days of computer graphics. Sophisticated finite element analyses, including 3D graphics representations of solutions, supported by direct analytical calculations including published methods for a wide range of applied mathematics problems relating to nanostructured materials. Analytical and FE solutions of flow patterns, diffusion profiles, scattering/diffraction phenomena, etc. Modeled structure-property relations in polymers. Modeling of thermodynamics, microstructures, spectroscopic and other measurements of complex structures.
2005-present: Chair, Government Relations Committee, Virginia Section of the American Chemical Society. Working to coordinate ACS member involvement in with governing bodies in science education, legislation and budgeting, as well as in student mentoring, equipment procurement for middle and high schools, and changes in science fair rubrics.
Authored an invited paper for the Journal of Virginia Science Education (JVSE) entitled “Teacher Access to Mentors through Professional Scientist Organizations: The Virginia Science Resource Network”.
Judge at Virginia State Science & Engineering Fair, Special Judge at Metro Richmond Science Fair, Virginia Junior Academy of Science fair; presentations at Career Days, SMV Lunch Series, Chemistry Week events, mentor science projects, etc.
2007-2010 Annual presentations at Professional Development Institute conferences of the Virginia Association of Science Teachers.
E. L. Thomas, D. M. Anderson, C. S. Henkee, D. Hoffman, “Periodic area‑minimizing surfaces in block copolymers”, Nature 1988, 334, 598‑601.
D. M. Anderson, S. M. Gruner and S. Leibler, “Geometrical aspects of frustration in the cubic phase of lyotropic liquid crystals”, Proc. Nat. Acad. Sci. 1988, 85, 5364‑5368.
D. M. Anderson, J. C. C. Nitsche, H. T. Davis, E. L. Scriven , “Periodic surfaces of prescribed mean curvature”, Adv. Chem. Phys., 1990, 77, 337‑396.
Pelle Ström and D. M. Anderson, “The cubic phase in the system didodecyldimethylammonium bromide ‑ water – styrene”, Langmuir, 1992, 8, 691-702.
D. M. Anderson, P. Ström, “Polymerization of lyotropic liquid crystals”, in: Polymer Association Structures: Liquid Crystals and Microemulsions, 1988, pp. 204‑224, ed. M. El‑Nokaly, ACS Symposium Series.
D. M. Anderson and H. Wennerström, “Self‑diffusion in bicontinuous cubic phases, L3 phases, and microemulsions”, J. Phys. Chem. 1990, 94, 8683‑8694.
D. M. Anderson, H. Wennerström, U. Olsson, “Isotropic, bicontinuous solutions in surfactant‑solvent systems: the L3 phase”, J. Phys. Chem. 1989 93, 4243‑4253.
H. Wennerström and D. M. Anderson, “Curvature energies in surfactant microstructures: the difference curvature. Applications to vesicle stability”, Statistical Thermodynamics and Differential Geometry of Microstructured Materials, Eds. H. T. Davis and J.C.C. Nitsche, Springer-Verlag, 1992.
D. M. Anderson, J. Bellare, J. T. Hoffman, D. Hoffman, J. Gunther and E. L. Thomas, “Algorithms for the computer simulation of two-dimensional projections from structures determined by dividing surfaces”, J. Coll. Int. Sci., 1992, 148, 398-414.
D. M. Anderson and Pelle Ström, “Polymerized lyotropic liquid crystals as contact lens materials”, Physica A, 1991, 176, 151-167.
D. M. Anderson, “A new technique for studying microstructures: 2H NMR bandshapes of polymerized surfactants and counterions in microstructures described by minimal surfaces”, Supplement to J. Physique, Proceedings of Workshop on Geometry and Interfaces, Aussois, France, Sept. 1990, C71‑1 ‑ C7‑18.
D. M. Anderson, D. C. Martin, and E. L. Thomas, “Maximum entropy data restoration using both real and Fourier space analysis”, Acta Cryst., 1989 A45, 686‑698.
D. M. Anderson, H. T. Davis, L. E. Scriven, “Mean and Gaussian curvatures of the randomly‑decorated Voronoi and cubes tessellations”, J. Chem. Phys., 1989 91 (5), 3246‑3251.
B. Lindman, Kozo Shinoda, U. Olsson, D. M. Anderson, G. Karlström, and H. Wennerström, “On the demonstration of bicontinuous structures in microemulsions”, Colloids and Surfaces, 1989 38, 205‑214.
D. M. Anderson and E. L. Thomas, “Morphology of star diblock copolymers in the strong‑segregation limit”, Macromolecules 1988 21, 3221‑3230.
D. M. Anderson and K. Frame, "Teacher access to mentors through professional scientist organizations and the Virginia Science Resource Network", J. Va. Sci. Ed., 2008 2(2):15-24.
Additional book contributions:Geometric Analysis and Computer Graphics, ed. P. Concus, #17 MSRI Series, Springer-Verlag, 1990; Lectures in Minimal Surfaces, J. C. C. Nitsche, Springer-Verlag; NSF Mosaic, "Computer Images in Five Dimensions", ed. W. Kornberg, 1988; Chemical & Engineering News, Aug. 1985; and Islands of Truth, Ivars Pearson, 1992.
PATENTS AND PATENT APPLICATIONS.
D. M. Anderson, U.S.Patent No. 7,713,440 (issued 2010) and associated European Patents currently in various stages of issuance, “Stabilized uncoated particles of reverse liquid crystalline phase materials.”
D. M. Anderson, U.S. Patent 7,838,515 (issued 2010) “Formulations of quaternary ammonium neuromuscular blocking agents”.
D. M. Anderson, U.S. Patent Application #20100316606, “Stabilized formulations of peptides and proteins”.
D.M. Anderson, U.S. Patent No. 5,244,799 (issued 1993) and associated European Patent #0292145, "Microporous materials," based on the polymerization of lyotropic liquid crystals.
D.M. Anderson, U.S. Patent No. 5,238,613 (issued 1993) "Preparation of polymeric hydrogel containing micropores and macropores."
C.H. Wick and D.M. Anderson, U.S. Patent No. 6,051,189 (issued 2000) “System and method for detection, identification and monitoring of submicron particles”.
D.M. Anderson, U.S. Patent Nos. 6,482,517 (issued 2002), 6,638,621 (issued 2003), and U.S. 6,989,195, and associated international patents, “Coated particle and methods of making and using the same”. Continuations of this patent line include U.S. 6,989,195 and U.S. 7,105,229.
D.M. Anderson, U.S. Patent No. 6,991,809 (issued 2005) “Particles with improved solubilization capacity”, and associated international filings.
D.M. Anderson, EPO Patent (EP 01998324.6) allowed and currently issuing in European countries, “Solvent Systems for Pharmaceutical Agents”, U.S. counterpart pending.
Additional patents granted and applications pending.
Courses taught.include graduate courses in Biomaterials, Biophysics, and Polymers (University at Buffalo). This included the development of a new post-graduate Polymers course.
Student supervision includes one PhD and two M.S. students (completed theses/degrees).
Other teaching experience includes Instructor for the Math sections of the MCAT, SAT, GRE and GMAT at Stanley Kaplan Educational Institute (Mpls. office), and tutoring in math, sciences, and engineering both as undergraduate and graduate student at the Univ. of Minnesota, 1974-1981.