Statistical Topology of Brain Nuclei to Understand Tourette Syndrome Tics
James Winslow
Keywords: Tourette Syndrome, Rosetta Stone
Understanding Tourette Syndrome tics is a Rosetta Stone for decoding how complex behavior is produced by the human brain. Single neurons and synapses are well understood and conveniently simulated. The inclusion of synapses are well understood and conveniently simulated. The inclusion of synaptic NMD receptor scaling and several levels of brain structure to model behavior is an interesting mathematical and computational question. A statistical and stochastic topological model is presented for large scale simulation of many brain nuclei with many neuron types per nuclei with intra and extra nuclei connections. This is an important step in development of a model which is almost everywhere biologically correct and sufficient for hypothesis testing and insight to clinical treatment.
